Position:
Group Leader – Structural Biology – Protein Production
Client: Dart
NeuroScience LLC (DNS) is a privately held Delaware Limited Liability Company
with offices in San Diego, CA. DNS will
discover new technologies and develop new therapies to help maintain cognitive
vitality throughout life. www.dartneuroscience.com
DNS is seeking a group leader
with extensive experience in large-scale protein production for macromolecular
crystallography studies.
Reporting to the director of
structural biology, the successful candidate will be responsible to establish
and manage the large-scale protein production facility within the group.
The candidate should have
excellent knowledge of the state-of-the-art equipment and processes to perform
large-scale recombinant expression in both prokaryotic and eukaryotic
(baculovirus and mammalian cells) systems of proteins originating from various
protein families to produce milligram-quantities of material suitable for
structural studies and/or other drug discovery purposes.
Major responsibilities will
include independent hands-on experimental work in addition to guiding a team of
scientists and research associates to ensure the optimal operation of the
large-scale protein production platform to organize workload according to
research priorities and to support successful protein crystallization.
The candidate will be
required to provide scientific expert advice to group members and have frequent
interactions with the molecular biologists, protein chemists and
crystallographers in the group on new ideas to enhance productivity and to
improve protein expression and purification yields.
Good communication skills,
leadership skills, project and sample management experience overseeing multiple
projects in parallel as well as capacity for strategic thinking are required.
Requirements & Responsibilities:
·
Ph.D.
in life science with thesis.
·
8+
years of relevant experience in recombinant large-scale protein expression to
support structural studies. Preferably
1+ year of industrial supervisory experience of Ph.D. scientists and research
associates.
·
Proven
hands-on experience in large-scale scale recombinant prokaryotic and eukaryotic
(baculovirus and mammalian cells) protein production, protein purification and
biochemical/biophysical screening techniques for protein characterization (e.g.
western blot, calorimetry, analytical ultracentrifugation, DLS, thermal
melting, protein MS, protein NMR).
·
Expert
knowledge in large-scale protein production platforms, recombinant protein
expression and protein analysis techniques preferably demonstrated through
peer-reviewed publications.
·
Knowledge
in other areas of structural biology (protein chemistry and crystallography) is
desirable.
·
Inter-disciplinary
knowledge of drug discovery (enzymology, cellular pharmacology, DMPK) is a
plus.
·
Demonstrated
independent thought/creativity in science.
·
Excellent
collaboration, communication (oral and written) and multitasking skills and
able to present work formally to Scientific Research Committees.
Opportunity: DNS offers competitive salaries and a great benefits package
including incentive bonuses, healthcare, vision, dental, long-term disability,
life insurance and a 401(k) retirement savings plan.
For Additional Information Contact: Bill Domann
