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Position: Group Leader – Structural Biology – Protein Production Client: Dart NeuroScience LLC (DNS) is a privately held Delaware Limited Liability Company with offices in San Diego, CA. DNS will discover new technologies and develop new therapies to help maintain cognitive vitality throughout life. www.dartneuroscience.com DNS is seeking a group leader with extensive experience in large-scale protein production for macromolecular crystallography studies. Reporting to the director of structural biology, the successful candidate will be responsible to establish and manage the large-scale protein production facility within the group. The candidate should have excellent knowledge of the state-of-the-art equipment and processes to perform large-scale recombinant expression in both prokaryotic and eukaryotic (baculovirus and mammalian cells) systems of proteins originating from various protein families to produce milligram-quantities of material suitable for structural studies and/or other drug discovery purposes. Major responsibilities will include independent hands-on experimental work in addition to guiding a team of scientists and research associates to ensure the optimal operation of the large-scale protein production platform to organize workload according to research priorities and to support successful protein crystallization. The candidate will be required to provide scientific expert advice to group members and have frequent interactions with the molecular biologists, protein chemists and crystallographers in the group on new ideas to enhance productivity and to improve protein expression and purification yields. Good communication skills, leadership skills, project and sample management experience overseeing multiple projects in parallel as well as capacity for strategic thinking are required. Requirements & Responsibilities: · Ph.D. in life science with thesis. · 8+ years of relevant experience in recombinant large-scale protein expression to support structural studies. Preferably 1+ year of industrial supervisory experience of Ph.D. scientists and research associates. · Proven hands-on experience in large-scale scale recombinant prokaryotic and eukaryotic (baculovirus and mammalian cells) protein production, protein purification and biochemical/biophysical screening techniques for protein characterization (e.g. western blot, calorimetry, analytical ultracentrifugation, DLS, thermal melting, protein MS, protein NMR). · Expert knowledge in large-scale protein production platforms, recombinant protein expression and protein analysis techniques preferably demonstrated through peer-reviewed publications. · Knowledge in other areas of structural biology (protein chemistry and crystallography) is desirable. · Inter-disciplinary knowledge of drug discovery (enzymology, cellular pharmacology, DMPK) is a plus. · Demonstrated independent thought/creativity in science. · Excellent collaboration, communication (oral and written) and multitasking skills and able to present work formally to Scientific Research Committees. Opportunity: DNS offers competitive salaries and a great benefits package including incentive bonuses, healthcare, vision, dental, long-term disability, life insurance and a 401(k) retirement savings plan. For Additional Information Contact: Bill Domann Cell: 415 726 9704 Office: 858 756 227 Email: [log in to unmask] Jovanna Bost Market Development & Business Relations The Domann Organization-Life Science Leadership Retained Search Services since 1988 www.domann.net [log in to unmask] 415 .726.9705