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If the results are strange, I'd suggest looking a bit more closely at the preprocessed data to see what may have gone wrong. I occasionally see people not quite using Dartel as described in the manual, which can lead to problems. Best regards, -John On 28 January 2013 10:26, ARE <[log in to unmask]> wrote: > Dear all, > > I am currently analyzing a large group of patients compared to controls > (total n=170) with VBM. About half the group is made with a T1 TFE SENSE > and the other half with a T1 FFE CLEAR, but this is balanced between > patients and controls. > I manually reoriented the scans to get proper allignment. > Using DARTEL part of the results seem to be outside the brain, suggesting > a problem with normalisation? With the conventional SPM method there is > less mismatch, looking more reliable. Do you have any suggestion how I can > improve the normalisation to MNI? Is DARTEL able to compare different but > comparable T1's? > Many thanks. > > Kind regards, > > ARE >