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you are right, if differ in location of activation, then doesn't make sense to compare them. thanks Jun On Wed, Jan 23, 2013 at 2:00 PM, Vladimir Litvak <[log in to unmask]>wrote: > Dear Jun, > > If your patiens and controls differ in locations of activations I'm > not sure it makes sense to compare them in the SPM statistical > framework. In any case, doing two separate group inversions is the > worst idea because that alone artificially induces differences between > the two groups. Either a single group inversion or separate individual > inversions are statistically sound. > > Best, > > Vladimir > > On Wed, Jan 23, 2013 at 5:16 PM, Jun Wang <[log in to unmask]> wrote: > > Dear Vladimir, > > I have a question related to source localization across groups. I > have > > two groups of EEG data,one control, one patient. If I want to compare the > > source activities across groups, should I do one time group inversion on > all > > subjects of two groups. or should I do two times group inversions for two > > groups respectively. I understand group inversion assume the same areas > are > > activated but to different degree. so if patients and control have > > different source pattern, should I do inversion individually on each > subject > > instead. > > > > thanks > > Jun >