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Dear Jun, If your patiens and controls differ in locations of activations I'm not sure it makes sense to compare them in the SPM statistical framework. In any case, doing two separate group inversions is the worst idea because that alone artificially induces differences between the two groups. Either a single group inversion or separate individual inversions are statistically sound. Best, Vladimir On Wed, Jan 23, 2013 at 5:16 PM, Jun Wang <[log in to unmask]> wrote: > Dear Vladimir, > I have a question related to source localization across groups. I have > two groups of EEG data,one control, one patient. If I want to compare the > source activities across groups, should I do one time group inversion on all > subjects of two groups. or should I do two times group inversions for two > groups respectively. I understand group inversion assume the same areas are > activated but to different degree. so if patients and control have > different source pattern, should I do inversion individually on each subject > instead. > > thanks > Jun