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***NB: Posted on behalf of Dr. Macedo-Ribeiro, whom you should contact for further information (e-mail address below).*** The Associate Laboratory IBMC-INEB is recruiting a highly motivated researcher to integrate a multidisciplinary team in the field of the Biochemistry and Structural Biology of enzymes associated with human diseases. A PhD in the appropriate disciplines is mandatory. Previous post-doctoral research experience and demonstrated skills in Biochemistry and Structural Biology are required. Contract: The fixed term contract is limited to 28 months and expected to begin on March 1st 2013. The monthly gross salary amounts to 3.191,82 Euros. Job description: The regulation of biological and pathological processes is achievable through specific inhibition, spatial and temporal compartmentalization, and post-translational modification of the intervening enzymes. Impairment of any of these regulative mechanisms often results in serious pathologies to which specific therapeutic approaches can be conceived by understanding the molecular details of enzyme specificity, as well as of their strict regulation. In order to address the role played by macromolecular interactions and/or regulation by post-translational modifications in enzyme activity and specificity, we use protein X-ray crystallography along with a plethora of complementary biophysical/biochemical techniques. We are especially interested in elucidating the molecular mechanisms of action of proteins associated with neurodegenerative and infectious diseases ( http://www.ibmc.up.pt/research/research-groups/protein-crystallography). Application deadline: 20/01/2013 All details required for application can be found at: http://www.eracareers.pt/opportunities/index.aspx?task=global&jobId=32498 Applications must be submitted online: http://www.ibmc.up.pt/institute/open-positions (position Ciência 2008 Substituição--CONT_DOUT/23/IBMC/316/10253/17/2008). For more information please contact: Dr. Sandra Macedo-Ribeiro Protein Crystallography Group IBMC- Instituto de Biologia Molecular e Celular Rua do Campo Alegre, 823 4150-180 Porto, Portugal (sribeiro_at_ibmc.up.pt) -- Pedro J. B. Pereira, PhD IBMC - Biomolecular Structure Group Rua do Campo Alegre, 823 4150-180 Porto Portugal Tel. +351 226 074 900 Fax +351 226 099 157 E-mail [log in to unmask]