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Yes, it is very common. I solved two of them at 2-3 A resolution and saw my colleague had one with 1.4 A resolution (can't remember the name of the protein). Please see references J Med Chem. 2010 Jul 22;53(14):5229-39. doi: 10.1021/jm100377f. Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement. Huang N, Kolhatkar R, Eyobo Y, Sorci L, Rodionova I, Osterman AL, Mackerell AD, Zhang H. Chem Biol. 2009 Aug 28;16(8):849-61. doi: 10.1016/j.chembiol.2009.07.006. Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD. Best, Nian On Mon, Jan 7, 2013 at 4:28 AM, Xiaopeng Hu <[log in to unmask]> wrote: > > Dear All, > > We recently resolved an enzyme/inhibitor complex structure. The enzyme contains two NCS related active site and we did find extra density in both of them.However we observed that the two inhbitor moleculors are not NCS related, but partly overlaped if make a NCS moleculor. Has anyone else observed this before? Thanks for any help and suggestion! > > > Best, > > Xiaopeng Hu >