Hello, Yeates twinning server; Phenix (and other possibilities). For detwinning, once you have a valid estimate of the twinning fraction (plus the twin law) you could use ccp4's detwin (this is the program I personally use). I think the name of the latter program tells what it does :-) . Fred. On 22/01/13 07:25, LISA wrote: > Hi all, > Does anyone know how to check a data is twin and how to detwin? > My data is 3.3 A with space group P6222 or P6422? But I can not solve > this structue by molecular replacement with the model has 42% sequence > identity. I am wondering my data maybe twin. > Thanks > Lisa -- Fred. Vellieux (B.Sc., Ph.D., hdr) IBS / ELMA 41 rue Jules Horowitz F-38027 Grenoble Cedex 01 Tel: +33 438789605 Fax: +33 438785494