THRIVE was limited to patients with very well controlled LDLc.  However, there is plenty of older evidence suggesting nicotinic acid is likely to be of benefit in the statin intolerant patient with elevated LDLc (albeit from the pre-statin era.....).

Best wishes

Ian

Prof.Ian S. Young

Professor of Medicine and Director of The Centre for Public Health

Queen's University Belfast

1st Floor ICS B Block

Royal Victoria Hospital

Grosvenor Road

Belfast

BT12 6BJ

Northern Ireland

tel: +44 (0) 2890 632743

fax: +44 (0) 2890 235900

email: [log in to unmask]

I never managed to get anyone to take Niaspan because the few I tried refused to tolerate the flushes. It is a shame that Tredaptive has gone because I have some statin-intolerant patients who were getting reasonable LDL reduction with it, but I shall not be trying to use nicotinic acid as the THRIVE trials data uggests it is a waste of time.

TIM

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Prof. Tim Reynolds
Consultant Chemical Pathologist / Associate Clinical Director - Diagnostics / R&D Lead,
Burton Hospitals NHS Foundation Trust
work tel: 01283 511511 ext 4035
work fax: 01283 593064
work email: [log in to unmask]
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From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Iversen Andrew (BRIGHTON AND SUSSEX UNIVERSITY HOSPITALS NHS TRUST)
Sent: 24 January 2013 10:50 AM
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Subject: Tredaptive is withdrawn

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------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/