THRIVE was limited to patients with very well controlled LDLc. However, there is plenty of older evidence suggesting nicotinic acid is likely to be of benefit in the statin intolerant patient with elevated LDLc (albeit from the pre-statin era.....). Best wishes Ian Prof.Ian S. Young Professor of Medicine and Director of The Centre for Public Health Queen's University Belfast 1st Floor ICS B Block Royal Victoria Hospital Grosvenor Road Belfast BT12 6BJ Northern Ireland tel: +44 (0) 2890 632743 fax: +44 (0) 2890 235900 email: [log in to unmask]<mailto:[log in to unmask]> From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Reynolds Tim (RJF) BHFT Sent: 24 January 2013 10:52 To: [log in to unmask] Subject: Re: Tredaptive is withdrawn I never managed to get anyone to take Niaspan because the few I tried refused to tolerate the flushes. It is a shame that Tredaptive has gone because I have some statin-intolerant patients who were getting reasonable LDL reduction with it, but I shall not be trying to use nicotinic acid as the THRIVE trials data uggests it is a waste of time. TIM ************************************************************************************** Prof. Tim Reynolds Consultant Chemical Pathologist / Associate Clinical Director - Diagnostics / R&D Lead, Burton Hospitals NHS Foundation Trust work tel: 01283 511511 ext 4035 work fax: 01283 593064 work email: [log in to unmask]<mailto:[log in to unmask]> work URL: www.burtonhospitals.nhs.uk<http://www.burtonhospitals.nhs.uk> This e-mail, and any files transmitted with it, are confidential and intended solely for the use of the individual to whom it is addressed. If you are not the intended recipient please destroy this message, delete any copies held on your systems, and notify the sender immediately. You should not retain copy or use this e-mail for any purpose, nor disclose all or any part of its content to any other person. If you have received this e-mail in error, please notify me on 01283 511511 Ext 4035 [Picture of tree not available] Please consider the environment before printing this e-mail ________________________________ From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Iversen Andrew (BRIGHTON AND SUSSEX UNIVERSITY HOSPITALS NHS TRUST) Sent: 24 January 2013 10:50 AM To: [log in to unmask]<mailto:[log in to unmask]> Subject: Tredaptive is withdrawn --- This message was sent from an email address external to NHSmail but gives the appearance of being from an NHSmail (@nhs.net) address. The recipient should verify the sender and content before acting upon information contained within. The identified sender is [log in to unmask]<mailto:[log in to unmask]> --- Dear Lipid Clinic Doctors Are you still precribing nicotinic acid? If so, how? regards Andrew ******************************************************************************************************************** This message may contain confidential information. If you are not the intended recipient please inform the sender that you have received the message in error before deleting it. Please do not disclose, copy or distribute information in this e-mail or take any action in reliance on its contents: to do so is strictly prohibited and may be unlawful. Thank you for your co-operation. 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ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/