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Dear SPM community, I have an experimental design with three independent groups each receiving one of three different treatments. This is expected to decrease activity in group A and increase activity in group C, as compared to placebo (group B). How can I incorporate this hypothesis in a single model on the second level? Would the solution be anything close to a design matrix like the following one: -1 0 0 0 0 0 0 0 1 Many thanks in advance for all answers and hints! Yoan -- Yoan Mihov, Dipl.-Psych. NEMO Research Group Department of Psychiatry University of Bonn Sigmund-Freud-Str. 25 53105 Bonn Germany Tel.: +49 (0)228 287 11165 web <http://renehurlemann.squarespace.com/team/>