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Hi - I guess this is mostly correct, but probably the handling of mean modelling / demeaning may be wrong - see Jeanette Mumford's web page on these issues. Cheers, Steve. On 27 Dec 2012, at 10:04, Ai Qing wrote: > Dear FSL experts: > > I colloected 56 patients with cognitive impairment consecutively. I want to analyses these data using TBSS, one group. All these patients had scores of cognitive scale. I want to observe the relationship between FA and the degree of cognitive impairment. > > I choose score of cognitive scale as main EVs, and age, sex, education as co-variates. The following are my design.mat and design.con files. > > design.mat: > > /NumWaves 4 > /NumPoints 55 > /PPheights 2.600000e+01 2.000000e+00 7.900000e+01 5.000000e+00 > > /Matrix > 2.200000e+01 2.000000e+00 6.400000e+01 1.000000e+00 > 2.300000e+01 2.000000e+00 6.800000e+01 2.000000e+00 > 1.500000e+01 2.000000e+00 6.100000e+01 3.000000e+00 > 2.600000e+01 1.000000e+00 7.400000e+01 1.000000e+00 > ............. > > > design.con: > > /ContrastName1 ev1_pos > /ContrastName2 ev1_neg > /NumWaves 4 > /NumContrasts 2 > /PPheights 1.630884e+01 1.630884e+01 > /RequiredEffect 2.339 2.339 > > /Matrix > 1.000000e+00 0.000000e+00 0.000000e+00 0.000000e+00 > -1.000000e+00 0.000000e+00 0.000000e+00 0.000000e+00 > > I don not know whether the above design is correct. > > Thanks!! > --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------