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The work by Kas et al (2007) http://jnm.snmjournals.org/content/48/9/1459.full.pdf+html (see Fig. 1) did use the SPM-PET template to standardize such specific dopamine maps. The second work by Vernaleken et al (2007) used AIR to do the image registration task. I believe once you build the first pass "specific" template, then it may be used to improve the procedure to maximize the mutual information. One can see that FDG or Flow maps (using PET, CT, SPECT, MRI-GAD, or ASL) contrast may be most similar to dopmaine trasporter density in deep GM (caudate, putamen, thalamus; accumbens?) and may differ in other regions (cingulate?). It would be great to see such "normative" dopmaine templates made publicly available following the pionnering steps of SPM developers as this would advance the interpretation of quantitative MRI metrics (i.e. T2, PD, DTI,..Hasan et al. 2012). Kas A, Payoux P, Habert MO, Malek Z, Cointepas Y, El Fakhri G, Chaumet-Riffaud P, Itti E, Remy P. Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images. J Nucl Med. 2007;48(9):1459-67. Vernaleken I, Weibrich C, Siessmeier T, Buchholz HG, Rösch F, Heinz A, Cumming P, Stoeter P, Bartenstein P, Gründer G. Asymmetry in dopamine D(2/3) receptors of caudate nucleus is lost with age. Neuroimage. 2007;34(3):870-8. Hasan KM, Steinberg JL, Moeller GF, MA L, Frye RE, Narayana PA. Healthy Human Brain and Patient Customized Quantitative MRI Templates and their interplay using VBM. Organization for Human Brain Mapping meeting in Beijing, China June 10-14, #643, 2012. Khader M Hasan, PhD Associate Professor of Radiology MSE 168, Tel 713 500 7690 (FAX 713 500 7684) University of Texas Health Science Center at Houston Medical School Diagnostic and Interventional Imaging Magnetic Resonance Imaging Research Division Diffusion Tensor Imaging Lab, Tel 713 500 7683 http://www.uth.tmc.edu/radiology/faculty/khader-m-hasan/index.html<http://www.uth.tmc.edu/radiology/faculty/hasan.html> ________________________________ From: SPM (Statistical Parametric Mapping) [[log in to unmask]] On Behalf Of KimMJ [[log in to unmask]] Sent: Wednesday, November 21, 2012 8:00 AM To: [log in to unmask] Subject: [SPM] PET template... Dear SPM experts I'm planning to analyze FP-CIT PET (a kind of dopamine transporter imaging) images in patients with Parkinson's disease. And my question is... Does anyone know of an FP-CIT PET template that can be freely downloaded ? If not, can I make a study-specific template using my data by way of direct normalization of each FP-CIT PET to a H2O PET template provided by SPM? Is this method valid? Any comments would be appreciated Thank you in advance for your help. MJ Kim