> Date: Mon, 12 Nov 2012 17:04:34 +0100
> From:
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[log in to unmask]> Subject: Re: [SPM] single subject clinical fMRI
>
> Hi Laura,
>
> the issue you are facing is not necessarily the size of your control
> population but the fact that you do not have variance in one of your
> "groups" (as n=1). Consequently, there are strong reservations against
> doing it this way. However, the need you see of course is there, and
> some groups have tried circumventing direct comparisons by creating
> z-score maps of "the usual" activation pattern (see Mbwana et al.,
> 2009). Also, VBM faces similar issues and a recent paper by Mühlau et
> al., 2009 includes some discussions on this issue. Perhaps this gives
> you some pointers on where to begin.
>
> Cheers,
> Marko
>
> Laura Bled wrote:
> >
> > Dear experts
> >
> > We are trying to find out what would be the most appropriate nr of
> > control subjects for our clinical fMRI experiment. We want to compare
> > single patients data to controls (a semantic task experiment). There are
> > 3 runs, block design. In already acquired data the activation per
> > subject, in controls or in patients is quite large. Is it appropriate to
> > compare 12 controls and 1 patients (a t-test) ?
> > I checked Rik Henson syntax on single case, but it's not quit the
> > response i was looking
> > for http://www.mrc-cbu.cam.ac.uk/people/rik.henson/personal/Henson_Singlecase_06.pdf
> >
> > Would be very grateful for any suggestions
> >
> > Laura
> >
>
> --
> ____________________________________________________
> PD Dr. med. Marko Wilke
> Facharzt für Kinder- und Jugendmedizin
> Leiter, Experimentelle Pädiatrische Neurobildgebung
> Universitäts-Kinderklinik
> Abt. III (Neuropädiatrie)
>
>
> Marko Wilke, MD, PhD
> Pediatrician
> Head, Experimental Pediatric Neuroimaging
> University Children's Hospital
> Dept. III (Pediatric Neurology)
>
>
> Hoppe-Seyler-Str. 1
> D - 72076 Tübingen, Germany
> Tel. +49 7071 29-83416
> Fax +49 7071 29-5473
>
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> http://www.medizin.uni-tuebingen.de/kinder/epn/
> ____________________________________________________