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Thank you very much!! 在 2012-11-29，上午3:39，Miro Drahos <[log in to unmask]> 写道： > FNIRT doesn't know anything about brains, it is an optimization routine. The different intensities in FLAIR and T1 images will mess things up. > What you want to do is FNIRT subjects T1 image to MNI and get the matrix for subject's FLAIR <--> T1 xfm (rigid body 6dofs transform enough, since it's the same brain). Then, combining the warp T1nat --> MNI with the matrix FLAIR --> T1nat you'll get FLAIR --> MNI. > Cheers, > Miro > > > On 11/25/2012 04:01 AM, Ai Qing wrote: >> Dear FSL experts: >> >> Is 3D FLAIR image not suitable for FNIRT to MNI152 image? I tried many times, but found the distortion is very obvious. Just like the following(Sorry to attach the image, I do not know how to describe) >> >> My 3D FLAIR data voxel size is 1*1*1mm^3. Fist register it to MNI152_T1_2mm using FLIRT. Then register it to MNI152_T1_2mm using FNIRT(default .cnf file). Finally resampling to MNI152_T1_1mm. >> <邮件附件.png> >