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So what would you make of the following comment: "Equipoise is an irrelevance. Patients are entered onto the trial because the trialists believe that the experimental treatment is better. The control group treatment should be as good as that available outside the trial. Experimentation continues until either the trialists are convinced they are wrong (equipoise is reached) or they convince Society they are right." Stephen Senn, as quoted at http://www.bmj.com/rapid-response/2011/10/28/placebo-confusion. Steve Simon, [log in to unmask], Standard Disclaimer. Sign up for the Monthly Mean, the newsletter that dares to call itself average at www.pmean.com/news