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Given prevalence of isolated raised ALT, prevalence of liver related pathology detected by AFP and its sensitivity and specificity in detecting disease, suspect calculation willshow that it's not a very effective suggestion with a lot of false +Ve patients having to be investigated?? dj -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Soha Zouwail Sent: 13 November 2012 15:00 To: [log in to unmask] Subject: Isolated raised serum ALT Dear all May I ask what comments you add to isolated raised serum ALT and which tests to do you suggest- Do you ask for all batteries of tests to exclude different causes? Do you have certain cut-offs for different suggestions? I know that fatty liver is a disease of exclusion but as it is becoming very common, it creates a significant cost to labs. Our gasteroenterologists have suggest to our GPs to add AFP among investigations. Thank you Best Wishes Soha Soha Zouwail Consultant Chemical Pathology University Hospital of Wales ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ This message contains confidential information and is intended only for the individual named. If you are not the named addressee you should not disseminate, distribute or copy this e-mail. Please notify the sender immediately by e-mail if you have received this e-mail in error and delete this e-mail from your system. If you are not the intended recipient you are notified that disclosing, copying, distributing or taking any action in reliance on the contents of this information is strictly prohibited. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/