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Hi Sandra, Yes, there are several ways of getting this information. Go to PDB website Advanced Search section. In the Query Type pull down, select All and then select "Remove Similar Sequences at 30% identity". You will have to select 30% cut off in the pull down menu. This will result in ~22000 structures out of ~85000 PDB entries. Fine tune the search by searching for only proteins (and xray or NMR). Also note that almost all structures deposited from the various centers of the PSI (Protein Structure Initiative) meet this criteria of novelty (many are actually in the 5-20% seq identity range). From the PDB website, click on Advanced Search. From the drop down menu, select "Structural Genomics Project" and under Centers select "All". You will see ~11500 entries. You can see some PSI metrics at: http://targetdb.pdb.org/Metrics/MilestonesTables.html In addition, the following papers will illustrate the PSI unique structures.: 1) http://www.ncbi.nlm.nih.gov/pubmed/16424331 Science. 2006 Jan 20;311(5759):347-51. The impact of structural genomics: expectations and outcomes. Chandonia JM, Brenner SE. Berkeley Structural Genomics Center, Physical Biosciences Division, Lawrence Berkeley National Laboratory, and Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA. 2) http://www.ncbi.nlm.nih.gov/pubmed/19787035 PLoS Biol. 2009 Sep;7(9):e1000205. Epub 2009 Sep 29. Exploration of uncharted regions of the protein universe. Jaroszewski L, Li Z, Krishna SS, Bakolitsa C, Wooley J, Deacon AM, Wilson IA, Godzik A. Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America. 3) http://www.ncbi.nlm.nih.gov/pubmed/19523904 Structure. 2009 Jun 10;17(6):869-81. PSI-2: structural genomics to cover protein domain family space. Dessailly BH, Nair R, Jaroszewski L, Fajardo JE, Kouranov A, Lee D, Fiser A, Godzik A, Rost B, Orengo C. Department of Structural and Molecular Biology, University College of London, London WC1E6BT, UK. [log in to unmask] Hope this helps. Thanks, Debanu. ________________________________________ From: CCP4 bulletin board [[log in to unmask]] On Behalf Of Sandra Quarantini [[log in to unmask]] Sent: Monday, October 15, 2012 3:53 AM To: [log in to unmask] Subject: [ccp4bb] unique structures HI! Does anybody know the number or a likely number of unique structures (solved by Xray) deposited in PDB every year???? (Unique structures I mean less than 30% identical in sequence to proteins for which structures had already been determined) I could not find this data šn PDB . Is eventually possible to get an estimate of this number by calculating the number of structures solved by MAD/SAD ...? thank you!!