Dear SPM experts, I ran a one-sample t-test with 5 temporal lobe epilepsy patients and my maximum t-value is 168. There are only a few voxels with extremely high t-values (located in the cerebellum and inferior frontal gyrus), while all other voxels have 'normal' t-values. I don't believe that the high t-values are due to one subject. I ran the analysis 4 times, each time excluding a different subject, and the maximum t-value always remained above 100. I also don't think the high values relate to the pre-processing pipeline I used, as my 12 controls look 'normal'. Is it possible that this is due to my small sample size? I would greatly appreciate any help on this matter. Thanks very much, Jenny ----- End forwarded message -----