Print

Print


Hi, thanks for the response! If the global FA is not accounted for do you have a simple solution to adding it as a covariate? It would be a big help as time is of the essence!

We did try to change the threshold with the tfce_corrp image and it lowered the significant voxel sizes and amounts but the significant clusters were still in one index # with 3000+ voxel size instead of 23000+.

We have also thought about using the fslroi tool but are unsure how to relate percentage of white matter region (labeled with the atlas tool in fslview) with voxel size of the given coordinates... Unless the voxel size is the 2nd row of numbers next to voxel xyz coordinates and then I just answered my own question...

Your thoughts and comments are greatly appreciated!

Thank you


Sent from my Verizon Wireless Phone

----- Reply message -----
From: "Stephen Smith" <[log in to unmask]>
To: <[log in to unmask]>
Subject: [FSL] FA value extraction
Date: Sat, Sep 1, 2012 3:11 am


Hi

On 31 Aug 2012, at 23:35, SUBSCRIBE FSL Nucleos wrote:

We are using TFCE to find differences in FA between two study groups using FSL. Similar to another question where they found more than 70000 voxels in a cluster, we are getting a cluster of 23000 voxels with good corrected p. However, when we visualize this cluster within FSLview, they are far apart. One significant cluster is in the forceps minor, another in the temporal part of the superior longitudinal fasciculus and another one in the anterior thalamic radiation. However, FSL assigns a single index number to a cluster of >23000 voxels that encompasses all these regions making it hard to extract FA values for further analysis outside of FSL. The documentation states that FSL accounts for global FA

Where?  I didn't think it does do this, or say that it does it in the doc!

But yes if you want to put in global mean FA as a covariate into randomise then that's fine.

while estimating regional differences in FA.

How can we create masks to extract the FA values from three regions of interest?

Or - in general if your clusters are too large wrt how you want to interpret them, you can just raise the corrp threshold so that they start to split up….?

Cheers.





---------------------------------------------------------------------------
Stephen M. Smith, Professor of Biomedical Engineering
Associate Director,  Oxford University FMRIB Centre

FMRIB, JR Hospital, Headington, Oxford  OX3 9DU, UK
+44 (0) 1865 222726  (fax 222717)
[log in to unmask]    http://www.fmrib.ox.ac.uk/~steve
---------------------------------------------------------------------------