HI Sandy, There is one over here : http://www.hindawi.com/journals/ari/2011/287860/ Maybe it will help you (after following the references) design a method for your specific case. Sid. On Sun, Sep 23, 2012 at 12:10 PM, Sandy Weser <[log in to unmask]> wrote: > Not sure if the body posted. here it is again: > > Hi, > > I am trying to co-register a 2D image from a brain histology slice to a 3D > T1-weighted MPRAGE structural MRI. Both are from the same subject. > > The brain slice image looks like this: > https://www.dropbox.com/s/1llyge0zih5bio1/brain_slice.jpg > > Does anyone know of a program that already does this in some way? Any > pointers to the problem would be much appreciated. > > The registration would probably have to involve more DOF than rigid-body, > since the tissue tends to shrink when put in the conservation solution > before the photograph is taken. > > Thanks, > Sandy >