Dear Colleagues,

Please pass this ad on to any interested candidates.

Thanks and best wishes,
John

-- 
John Rubinstein
Molecular Structure and Function Program
The Hospital for Sick Children
555 University Avenue, Rm. 3330
Toronto, ON
Canada
M5G 1X8
Tel: (+001) 416-813-7255
Fax: (+001) 416-813-5022
www.sickkids.ca/research/rubinstein

Project and laboratory:
A Postdoctoral position is available for the structural analysis of protein complexes by electron cryomicroscopy (cryo-EM). Projects relate to the analysis of protein complexes involved in endocytosis and vacuolar sorting and/or bacterial and viral proteins that interact with eukaryotic V-type ATPases. Candidates interested in studying other protein complexes, particularly membrane protein complexes, are also encouraged to apply. Applicants should have a PhD in biochemistry, biophysics, biological chemistry, or a related discipline. A background in structural biology is helpful but is not absolutely required. Please send applications, including a complete CV and contact information for three referees to: [log in to unmask]

The Rubinstein group is a small and interactive group comprised of members with diverse scientific backgrounds. We combine in-depth study of systems of biological and biomedical interest with expertise in cryo-EM technology and research into cryo-EM method development. By maintaining strong connections between biology and methodology, we ensure that our biological results are of the highest-possible quality and our methodological developments are useful for ‘real world’ problems. For more information, please visit www.sickkids.ca/research/rubinstein

The research environment and city of Toronto:
Located in the heart downtown Toronto, The Hospital for Sick Children’s Research Institute includes approximately 225 Principal Investigators, 1,140 graduate students and postdoctoral fellows, and 800 other scientific staff. Research in the Institute spans from basic biology to clinical practices with seven research programs including Molecular Structure and Function, Cell Biology, Genetics and Genome Biology, and Developmental and Stem Cell Biology. The Research Institute is affiliated with the University of Toronto, which is ranked 1st in Canada and 19th worldwide in the Times Higher Education World University Rankings (9th worldwide out of public universities). Toronto is Canada’s largest city and North America’s 5th largest city. It is one of the world’s most multicultural cities with vibrant arts and culture communities. Despite its size, it is also one of North America’s safest cities and is ranked as the 4th most liveable city in the world by The Economist Intelligence Unit's Global Liveability Report.

Selected Recent publications:
Benlekbir, S., Bueler, S. A., Rubinstein, J. L. (2012). Structure of the vacuolar-type ATPase from Saccharomyces cerevisiae. Nature Structural and Molecular Biology, In Press.

Baker, L. A., Watt, I. N., Runswick, M. J., Walker, J. E., Rubinstein, J. L. (2012). The arrangement of subunits in intact mammalian mitochondrial ATP synthase determined by cryo-EM. Proceedings of the National Academy of Sciences (USA) 109, 11675-80. (chosen by Faculty of 1000: f1000.com)

Lau, W. C. Y., and Rubinstein, J. L. (2012). Sub-nanometer resolution structure of the intact T. thermophilus H+-driven ATP synthase. Nature 481, 215-8. (chosen by Faculty of 1000: f1000.com)

Lau, W. C. Y., and Rubinstein, J. L. (2010). Structure of intact Thermus thermophilus V-ATPase by cryo-EM reveals organization of the membrane-bound Vo motor. Proceedings of the National Academy of Sciences (USA) 107, 1367-72. (chosen by Faculty of 1000: f1000.com)