Hi Louise

Since we moved to Roche Cobas c6000 nearly 4 years ago, I regularly see HDL-cholesterol results >3.5mmol/L.

I reported my concerns to Technical Support straight away, during the comparison stages and have not received a satisfactory answer yet. I had been raising it regularly at Roche User Meetings, sorry Roche Symposia, and during our MLS meetings.

I have an enormous amount of cumulative patient data where it cannot be possible for all patients to have changed meds, joined trials, developed liver disease.

I just do not believe the high HDL-cholesterols. Saying that, I do not comment on them and have received no enquiries from our GPs.

Best wishes

Gail

Dr Gail Curtis
Consultant Clinical Biochemist
Dept of Clinical Biochemistry
Glan Clwyd Hospital

BCUHB

Ffôn • Tel: (01745) 445293

(WHTN 1815 5293)

From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Louise Ward
Sent: 14 September 2012 11:41
To: [log in to unmask]
Subject: Raised HDL

Dear All,

I would very grateful for any thoughts about HDL results above 3.5 mmol/L.

Anecdotally we are seeing an increasing number of these results, often with fairly average total cholesterol and low LDL (<2). Does anyone routinely make a comment about these HDL results? Or about the LDL calculation (or remove it)? Is further testing done/recommended? Is this real? Assay interference? Is this protective for the patient?

Best wishes, Lou

Dr Louise Ward FRCPath

Clinical Scientist

Bedford

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