Dear SPM experts, <br><br>I was wondering if you could just check my logic to make sure I am on the right path with my analysis (or redirect me as necessary!). I am running a PET experiment with two groups (treatment and placebo) over two time points (baseline and post-treatment). From what I can tell from the list archives, the simplest approach seems to be to calculate a subtraction image (baseline - post-treatment) then run unpaired t-tests to identify differences. The t-contrast would be 1, -1 to identify regions of greater metabolism at post-treatment (compared to baseline) in the treatment group (compared to placebo).<br>
<br>Any comments would be greatly appreciated - just getting my head around the meaning of contrasts when a subtraction image has been calculated has nearly killed me!<br><br>Kind regards,<br><br>- Charles<br><br><br><br>
<br clear="all"><br>-- <br><b><font color="#990000">Charles Malpas </font></b><div>Master of Psychology (Clinical Neuropsychology) / PhD Candidate<br>Melbourne School of Psychological Sciences &amp; Department of Medicine (RMH)<br>
<div>The University of Melbourne 3010</div><div><br></div><div><b><font color="#000066">Melbourne Brain Centre @ RMH</font></b></div><div><span style="background-color:rgb(255,255,255)">Neuropsychiatry Research Group<b> </b></span></div>
<div>Level 4, Main Building, Royal Melbourne Hospital<br>Phone: 0451 116 434<br>Email: <a href="mailto:[log in to unmask]" target="_blank"><a href="/cgi-bin/wa-jisc.exe?LOGON=A3%3Dind1208%26L%3DSPM%26E%3Dquoted-printable%26P%3D5179739%26B%3D--20cf3079b8fc91bd5b04c8762a94%26T%3Dtext%252Fhtml%3B%2520charset%3DISO-8859-1%26pending%3D" target="_parent" >[log in to unmask]</a></a><br>Skype: charles.malpas</div></div>
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