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Dear SPM experts, I was wondering if you could just check my logic to make sure I am on the right path with my analysis (or redirect me as necessary!). I am running a PET experiment with two groups (treatment and placebo) over two time points (baseline and post-treatment). From what I can tell from the list archives, the simplest approach seems to be to calculate a subtraction image (baseline - post-treatment) then run unpaired t-tests to identify differences. The t-contrast would be 1, -1 to identify regions of greater metabolism at post-treatment (compared to baseline) in the treatment group (compared to placebo). Any comments would be greatly appreciated - just getting my head around the meaning of contrasts when a subtraction image has been calculated has nearly killed me! Kind regards, - Charles -- *Charles Malpas * Master of Psychology (Clinical Neuropsychology) / PhD Candidate Melbourne School of Psychological Sciences & Department of Medicine (RMH) The University of Melbourne 3010 *Melbourne Brain Centre @ RMH* Neuropsychiatry Research Group* * Level 4, Main Building, Royal Melbourne Hospital Phone: 0451 116 434 Email: [log in to unmask] Skype: charles.malpas