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Hi - yes I believe so. However, a better way to do it is to perform tractography directly in standard space, providing probtrackx with the transformations between diffusion and standard space. In that case, the binning of the spatial histogram will be done directly in standard space, and you don't need to worry about the interaction between local contraction/expansion and interpolation. Cheers Saad On 30 Aug 2012, at 14:59, SUBSCRIBE FSL Jay wrote: > Hello, > > I would like to perform voxelwise comparison on fdt_paths data between 2 groups. I wanted to make sure if i need to perform volume correction when i co-register the fdt_paths from diffusion space to standard space before performing the voxelwise statistics (using randomise)? > > BW > Jay > -- Saad Jbabdi University of Oxford, FMRIB Centre JR Hospital, Headington, OX3 9DU, UK (+44)1865-222466 (fax 717) www.fmrib.ox.ac.uk/~saad