Dear Colleagues,
We had a query from
our Endocrinologist regarding a high SHBG concentration on a 22 year
old lady presenting with secondary
amenorrhea of no obvious cause. Definitely not on contraceptive pills or other exogenous oestrogens. Otherwise fit &
well.......
Euthyroid and not pregnant!
Her blood tests
were:
05/04/12
Serum
albumin 52
g/L 35 -
52
Serum
LH
* 1.2
iu/L 2.4 -
13 *
low
Serum
FSH 3.9
iu/L 3.5 -
13.0
Day
of
cycle Not
stated
Serum
total
testosterone 0.4
nmol/L 0.29 -
1.67
Serum
SHBG * >200
nmol/L 25 -
122 *
high
28/06/12
Serum
albumin 50
g/L 35 -
52
THYROID FUNCTION
TESTS_
Serum
TSH 0.79
mu/L 0.3 -
4.2
Serum free
thyroxine 12.5
pmol/L 12 -
22
Serum
LH * <1.0
iu/L 2.4 -
13 * low
Serum
FSH 4.5
iu/L 3.5 -
13.0
Serum
prolactin 104
miu/L
102 -
496
Serum
progesterone * 1.9
nmol/L 5.3 -
86 * low
Day of
cycle
Serum
total
testosterone 1.1
nmol/L 0.29 -
1.67
Serum
SHBG * >200
nmol/L 25 -
122 *
high
Serum
hCG Not
detected
LFT normal in previous samples.
Interference by heterophilic antibodies has been
excluded by using blocking tubes and also sending the sample to an external
lab using a different platform, result remained
high.
Thank
you
Kind
Regards
Dr Fayha Ahmed
SpR Chemical Pathology
Dept of Clinical
Biochemistry
RSCH
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