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Emma, Thanks for the question. We approach this differently and correct for the effect of haemolysis with an algorithm. If uncertainty of the correction is large we add a footnote indicating that the result has a larger uncertainty (ie up to +/- 20%). This correction includes all haemolysis indices including very low ones (eg 0 or 10 or 20 mg/dL) although the effect is very small at these levels. As this is an off-label use of the test we had our validation of this approach assessed by NATA (the Australian Accreditation body) as an in-house IVD and this was accepted. From a measurement uncertainty approach when we have a bias, in this case due to an interference from haemolysis, we should remove the bias and add the uncertainty of the removal process to the uncertainty of the result. I attach a poster from the AACB meeting in 2010 where we presented the data (copywrite with the AACB). Obviously if anyone else wants to do this they should perform their own studies. Regards, Graham >>> "Connell Emma (CROYDON HEALTH SERVICES NHS TRUST)" <[log in to unmask]> 08/02/12 6:33 PM >>> Dear all, Would any Roche modular users out there mind sharing the haemolysis index value at which results for the troponin T hs assay are not reported? The insert says no interference at haemoglobin concentrations below 0.1 g/dL but with a warning that any visible sign of haemolysis can cause problems. We have our index set at 50 but would be interested to hear what others are doing. Many thanks, Emma Connell Emma Connell Trainee Clinical Scientist Croydon University Hospital 530 London Road Thornton Heath Surrey CR7 7YE ******************************************************************************************************************** This message may contain confidential information. If you are not the intended recipient please inform the sender that you have received the message in error before deleting it. Please do not disclose, copy or distribute information in this e-mail or take any action in reliance on its contents: to do so is strictly prohibited and may be unlawful. Thank you for your co-operation. NHSmail is the secure email and directory service available for all NHS staff in England and Scotland NHSmail is approved for exchanging patient data and other sensitive information with NHSmail and GSi recipients NHSmail provides an email address for your career in the NHS and can be accessed anywhere ******************************************************************************************************************** ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ********************************************************************** This email and any files transmitted with it are confidential and intended solely for the use of the individual or entity to whom they are addressed. If you have received this email in error please notify the system manager. This footnote also confirms that this email message has been virus scanned and although no viruses were detected by the system, St Vincents & Mater Health Sydney accepts no liability for any consequential damage resulting from email containing any computer viruses. ********************************************************************** ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/