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Hi I don't think Jay was thinking of using fdt_paths for registration, but rather using them as statistics for comparison between groups (after using other images for registration, like FA etc.) I think it is fine to use fdt_paths for statistical comparisons, although they may have some weird spatial properties that tools like TFCE etc. have not been properly tested on. Other than that, you will need, of course, to do non-parametric inference (e.g. randomise) and you will need to be careful with interpretation. Saad On 10 Jul 2012, at 16:41, Sourena Soheili wrote: > Hi > This doesn't sound like a descent choice to me. Probably, TBSS is the > best tool for comparison of the diffusion data at the moment. I am not > aware of a good candidate for registration of tractography images, and > considering tract crossings and entanglements, maybe there is > basically no diffeomorphic means of intersubject tract registration. > In case you insist on this, I suggest to work in the connectivity > domain of the frontal cortex after surface registration, not the raw > tractography images. Probably others may have better ideas. > > Cheers, > Sourena > > On 7/10/12, SUBSCRIBE FSL Jay <[log in to unmask]> wrote: >> Hello, >> >> I would like to perform tractography in the frontal lobe of the brain for a >> group of 20 patients and 20 controls. I was wondering if it is possible to >> perform voxelwise statistics on fdt_paths ( 3d fiber image ) after >> transforming them into standard space, to see the differences between >> patients and controls? >> >> BW >> Jay >> > -- Saad Jbabdi University of Oxford, FMRIB Centre JR Hospital, Headington, OX3 9DU, UK (+44)1865-222466 (fax 717) www.fmrib.ox.ac.uk/~saad