Hi Cathy,

This is a great question - a statistically significant reduction is likely to require a very large sample size (probably beyond the realm of most RCTs). However, if I understand your email correctly, you want to know what would be meaningful reduction in clinical terms. I don't have an answer but I look forward to reading the discussion.

Best wishes

Vanora

________________________________________
From: A forum for discussion on midwifery and reproductive health research. [[log in to unmask]] On Behalf Of Cathy Walton [[log in to unmask]]
Sent: 01 June 2012 12:01
To: [log in to unmask]
Subject: Advice wanted

Dear Midwifery research group members,
I am a consultant midwife at King's College Hospital in London and have
been a member of this group for a number of years and rarely contribute
but always find the discussions interesting. Sadly, I don't get to do
much research in my job, as it really isn't easy to have time for it.
However, recently I have been involved in the planning of 2 possible
RCTs and would like to pick the brains of the esteemed members of this list.

Would anyone have any suggestions for what would be a clinically
significant % point reduction in the casaerean section rate if used as a
a primary outcome?
If so, can you direct me to any evidence or reference that might be
useful to base this on?

Many thanks,
Cathy Walton

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