Hi Cathy,
This is a great question - a statistically significant reduction is likely to require a very large sample size (probably beyond the realm of most RCTs). However, if I understand your email correctly, you want to know what would be meaningful reduction in clinical
terms. I don't have an answer but I look forward to reading the discussion.
Best wishes
Vanora
________________________________________
From: A forum for discussion on midwifery and reproductive health research. [[log in to unmask]] On Behalf Of Cathy Walton [[log in to unmask]]
Sent: 01 June 2012 12:01
To: [log in to unmask]
Subject: Advice wanted
Dear Midwifery research group members,
I am a consultant midwife at King's College Hospital in London and have
been a member of this group for a number of years and rarely contribute
but always find the discussions interesting. Sadly, I don't get to do
much research in my job, as it really isn't easy to have time for it.
However, recently I have been involved in the planning of 2 possible
RCTs and would like to pick the brains of the esteemed members of this list.
Would anyone have any suggestions for what would be a clinically
significant % point reduction in the casaerean section rate if used as a
a primary outcome?
If so, can you direct me to any evidence or reference that might be
useful to base this on?
Many thanks,
Cathy Walton
The University of Stirling is ranked in the top 50 in the world in The Times Higher Education 100 Under 50 table, which ranks the world's best 100 universities under 50 years old.
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