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Dear Caty I am Camilla Schneck from Brazil. Your question is really important But in some cases depends on the seeting I mean Hera in Brazil ouir c-section rate is about 54% in a whole country and about 80% in private sector. And in our setting how much is expected to reduce? And which intervention you want to test? So I think is needed to think about the seeting and the intervention I hope that I could to colaborate With best regards Camilla Profa Dra Camilla Schneck Curso de Obstetrícia Escola de Artes Ciências e Humanidades Universidade de São Paulo Av Arlindo Bettio, 1000 03828-000 São Paulo - Brasil Edifício I-1 - Sala 252 skype name: camilla_midwife www.each.usp.br Cause boa impressão: imprima só o necessário! A natureza agradece! --- Em sex, 1/6/12, Vanora Hundley <[log in to unmask]> escreveu: De: Vanora Hundley <[log in to unmask]> Assunto: Re: Advice wanted Para: [log in to unmask] Data: Sexta-feira, 1 de Junho de 2012, 10:37 Hi Cathy, This is a great question - a statistically significant reduction is likely to require a very large sample size (probably beyond the realm of most RCTs). However, if I understand your email correctly, you want to know what would be meaningful reduction in clinical terms. I don't have an answer but I look forward to reading the discussion. Best wishes Vanora ________________________________________ From: A forum for discussion on midwifery and reproductive health research. [[log in to unmask]] On Behalf Of Cathy Walton [[log in to unmask]] Sent: 01 June 2012 12:01 To: [log in to unmask] Subject: Advice wanted Dear Midwifery research group members, I am a consultant midwife at King's College Hospital in London and have been a member of this group for a number of years and rarely contribute but always find the discussions interesting. Sadly, I don't get to do much research in my job, as it really isn't easy to have time for it. However, recently I have been involved in the planning of 2 possible RCTs and would like to pick the brains of the esteemed members of this list. Would anyone have any suggestions for what would be a clinically significant % point reduction in the casaerean section rate if used as a a primary outcome? If so, can you direct me to any evidence or reference that might be useful to base this on? Many thanks, Cathy Walton The University of Stirling is ranked in the top 50 in the world in The Times Higher Education 100 Under 50 table, which ranks the world's best 100 universities under 50 years old. The University of Stirling is a charity registered in Scotland, number SC 011159.