Thanks a lot dear Anna,

As I have mentioned I have only 23 controls which may not be sufficient to make a DARTEL template out of them, so I may go for the VBM8 template?!

cheers,

Shahrzad

From: "Dzieciol, Anna" <[log in to unmask]>
To: shahrzad kharabian <[log in to unmask]>
Sent: Friday, May 4, 2012 2:10 PM
Subject: RE: [SPM] DARTEL TEMPLATE

Hi Shahrzad,

You shouldn’t include highly abnormal brains in a Dartel template. One option is to create a template based on controls only, using ‘Dartel-Create Templates’, and then align both patients and controls to this template. Another option is to use VBM8 toolbox, which has its own Dartel template derived from a large number of brains. I’ve been also told that VBM8 toolbox is also sometimes better for segmenting highly abnormal brains.

All the best,

Anna

From: SPM (Statistical Parametric Mapping) [mailto:[log in to unmask]] On Behalf Of shahrzad kharabian
Sent: 04 May 2012 09:21
To: [log in to unmask]
Subject: [SPM] DARTEL TEMPLATE

Dear experts,

I have a question regarding the use of DARTEL template for a VBM study.

If I have 5 groups of subjects which 4 groups (each group has about 14 subjects) do NOT have normal brains (because of a special disease the brains are highly malformed) and just one group is the control group (with about 23 subjects) and all subjects are very old, do you recommend to make a DARTEL template for them or would it be better to use MNI template?
brains in different groups are rather different as each group is in a specific stage of the disease (except the control group).

If yes, then I assume that I have to use all 5 groups to make the template? (even all subjects from the control group?)

I am also wondering if using the new segment option would helpful in my case?

THanks in advance