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I'd suggest you do the same as in the examples in the SPM manual - until you have figured out why each step may occasionally be used. The actual options (ie register only, reslice only or register and reslice) are also documented in the manual, as well as on the user interface of the batching system. Best regards, -John On 23 May 2012 16:53, Adrienne Hezghia <[log in to unmask]> wrote: > Dear experts, > > In preprocessing, does when does one do realign (estimate) v. realign > (reslice), and coregister (estimate) v. coregister (reslice)? What > outputs do each of these generate? > > Thank you, > Adrienne