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Hi, I have some problem with normalise. I have to do a non-linear coregistration between two images of the same patient. The original images don't have the same dimension between, so I did a linear coregistration (button coregistration estimate/write). I used one of the two images as template. I cecked the output with CheckReg, they seems to have a good alignment. Then I used normalise (estimate/write), the template is the same used in coregistration. The output image is very bad. The images are in http://hpmagic5.unile.it/BRAIN_IMAGE/SPM P_Normalized_biopsyBesideTumor.nii is the image used as template. P_Dec2011.nii is the image that I want to coregister. rP_Dec2011.nii is the output after coregistration. wrP_Dec2011.nii is the output after normalise. Could you help me? let me know where is the problem. Many thanks and best wishes. Alessandra Carla'