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(1) Find the mean of the x,y,z coordinates of each cluster;

(2) Find the weighted mean of the x,y,z coordinates of each cluster; or

(3) Find the mean of the x,y,z coordinates of all the peaks in the cluster or peaks with 8mm of each other as done with peak_nii.

The one thing to note is that all of these methods could move the center outside of the cluster if the cluster is shaped in an odd way. This is less likely to happen if you only find the peaks in the cluster and find the center of them within 8mm of each other.

Hope this helps.

Best Regards, Donald McLaren
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D.G. McLaren, Ph.D.
Postdoctoral Research Fellow, GRECC, Bedford VA
Research Fellow, Department of Neurology, Massachusetts General Hospital and
Harvard Medical School
Website: http://www.martinos.org/~mclaren
Office: (773) 406-2464
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