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Hi mojdeh, Yes, it's fine to do this. Regards, Vince ------Original Message------ From: Mojdeh Z Sender: SPM List To: SPM List ReplyTo: Mojdeh Z Subject: [SPM] t-test on ICA results Sent: Mar 12, 2012 10:35 AM Dear SPMers, I was wondering if I can use SPM to do one and two sample t-test on the results of GIFT ICA. More specifically, I have two groups of controls and patients and I have identified the DMN component of each subject using GIFT, now I want to perform a voxel-wise one and two sampel t-test on the subject component maps. Thanks for your help in advance, Mojdeh Zamyadi, MSc Clinical Research Project Assistant The Hospital for Sick Children 555 University Avenue Toronto ON M5G 1X8 _____________________________________ Vince D. Calhoun, Ph.D. Chief Executive Officer and Director Image Analysis & MR Research The Mind Research Network Professor Depts. of Electrical and Computer Engineering (primary), Neurosciences, Psychiatry, and Computer Science University of New Mexico