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Dear All, If someone can please help me sort out a confusion: If I do a High Dimensional Warping from image A onto image B. I have 2 files created. (i) yA (the deformation field) (ii) jyA (the Jacobian determinants) I then wish to compare the grey matter segmentations of both A and B but with their volumes preserved (assuming A and B are the images of the brain of the same person from a longitudinal study). If I multiply the grey matter segmentation of image A by jyA, do I get the 'evolution' of the voxels from A to B? Is the reverse possible? That is divide image B by jA to get the reverse of how the voxels have been transformed? Many thanks for your kind replies. Shail