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Hi all, Any help would be very appreciated. I have two conditions design and two sessions. The number of trials per condition is defined by subject's response in the scanner. So, I end up with different number of repetitions per condition. 1. If in first session I have more trials of condition 1 and in the second session I have more trials of condition 2, would it be incorrect to define a general t-contrast [1 -1 1 -1]? Clearly, I can equalize and take for each session the minimal number of trials, but then I lose some data. 2. Does it make sense to put the weights on contrast definition? How would look a t-contrast if let's say in cond1 I have 10 trials and in cond2 only 5? Thanks a lot, John