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Dear All, I am in search for an SPM-based registration protocol for intrasubject pre and post operative (resective epilepsy surgery) MRI coregistration, preferably validated. Resections are sublobar in size, MRs are done 4 months apart, there is some cortical retraction/widened ventricles seen postop. Both scans are 3T MPRAGE/T1 without contrast done on the same scanner. I am able to generate postop MR masks excluding the resection based on a pial surface calculated with FreeSurfer, if cost function masking (Brett 2002) is needed. I would appreciate protocols for 1) direct pre-postop registration, and/or 2) normalization of both scans to the MNI space. The goal is to define the resection volume as volume of interest. I appreciate your advice. Thank you, Octavian Lie, uthscsa.