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What is your hypothesis? Peace, Matt. -----Original Message----- From: FSL - FMRIB's Software Library [mailto:[log in to unmask]] On Behalf Of Rajagopalan, Venkateswaran Sent: Friday, March 23, 2012 11:26 AM To: [log in to unmask] Subject: Re: [FSL] Gray Matter DTI Thanks Saad, could you tell me whether axial diffusivity be an appropriate measure to study changes in GM or what measures of DTI will be more appropriate to study GM changes. Thanks a lot Venkat ________________________________ From: FSL - FMRIB's Software Library on behalf of Saad Jbabdi Sent: Fri 3/23/2012 8:52 AM To: [log in to unmask] Subject: Re: [FSL] Gray Matter DTI Hi Dear All, I am interested in studying DTI changes (MD, I am wondering whether it will appropriate to study axial diffusivity also in the sense for instance FA is more for WM than GM) in gray matter between control and our patient population. I am wondering what is way to segment white matter (WM) from gray matter (GM). You can use FAST on a T1-weighted image and map back onto DTI space using FLIRT. I am also interested in extracting different lobes of the brain to study GM changes in each lobe. Basically based on our VBM results where I see GM volume changes I would like to study whether DTI measure MD changes in frontal, temporal, occipital and parietal lobes. If so, is there a way I can use the atlases to separate out different lobes of the brain. You can use the MNI structural atlas in fslview. Saad Thanks Venkat =================================== Please consider the environment before printing this e-mail Cleveland Clinic is ranked one of the top hospitals in America by U.S.News & World Report (2010). Visit us online at http://www.clevelandclinic.org <http://www.clevelandclinic.org/> for a complete listing of our services, staff and locations. Confidentiality Note: This message is intended for use only by the individual or entity to which it is addressed and may contain information that is privileged, confidential, and exempt from disclosure under applicable law. If the reader of this message is not the intended recipient or the employee or agent responsible for delivering the message to the intended recipient, you are hereby notified that any dissemination, distribution or copying of this communication is strictly prohibited. If you have received this communication in error, please contact the sender immediately and destroy the material in its entirety, whether electronic or hard copy. Thank you. -- Saad Jbabdi University of Oxford, FMRIB Centre JR Hospital, Headington, OX3 9DU, UK (+44)1865-222466 (fax 717) www.fmrib.ox.ac.uk/~saad =================================== Please consider the environment before printing this e-mail Cleveland Clinic is ranked one of the top hospitals in America by U.S.News & World Report (2010). Visit us online at http://www.clevelandclinic.org for a complete listing of our services, staff and locations. Confidentiality Note: This message is intended for use only by the individual or entity to which it is addressed and may contain information that is privileged, confidential, and exempt from disclosure under applicable law. If the reader of this message is not the intended recipient or the employee or agent responsible for delivering the message to the intended recipient, you are hereby notified that any dissemination, distribution or copying of this communication is strictly prohibited. If you have received this communication in error, please contact the sender immediately and destroy the material in its entirety, whether electronic or hard copy. Thank you.