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Dear SPM list, We have an fMRI paradigm where participants anticipate an anxiety provoking task in the scanner while viewing a timer counting down from three minutes. When the timer has reached zero, the anxiety provoking task is performed outside the scanner. During another three-minute paradigm, participants view random numbers. Participants are also presented with a third paradigm between the two paradigms. The order is as follows: 1. random numbers 2. another paradigm 3. anticipation paradigm Our question regards how to analyze the anticipation paradigm. We were thinking about using the random numbers paradigm as the control block and the anticipation paradigm as the experimental block. Could this be done with only one three-minute experimental block, and with the two blocks from different runs, or do we need some sort of baseline from each run? An alternative could be to model only the last minute of both paradigms. Another alternative we have thought about is to rather do a connectivity analysis more or less like resting state (e.g. with a seed in an ROI)? Any suggestions are highly appreciated. Best regards, Andreas