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Dear All: I have two questions. 1. Are there any difference in algorithms used for corrections for multiple comparisons between SPM5 and SPM2? My impression is that SPM5 is more restrict than SPM2. For example, if I used height threshold p < .01, a cluster of 100 voxels usually can survive correction in SPM2, but SPM5 needs about 250 voxels. 2. Is it reasonable to use AlphaSim from AFNI to decide cluster size? I noticed that AlphaSim needs much smaller clusters to survive correction relative to SPM5. Best Regards Jiansong The information contained in this message may be privileged and confidential. If you are NOT the intended recipient, please notify the sender immediately with a copy to [log in to unmask] and destroy this message. Please be aware that email communication can be intercepted in transmission or misdirected. Your use of email to communicate protected health information to us indicates that you acknowledge and accept the possible risks associated with such communication. Please consider communicating any sensitive information by telephone, fax or mail. If you do not wish to have your information sent by email, please contact the sender immediately. =============== Jiansong Xu, M.D., Ph.D. Assistant Professor Dept. of Psychiatry Yale Medical School 1 Church St., Room 729 New Haven, CT 06519 Tel: 203-785-5306 Fax: 203-737-3591