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Hi there, I had setup 2 groups in the groups column, and when I added the single column covariate to the interaction model I'll have the problem of not separable EVs. Maybe an important piece of information is that the different acquisition parameters are only in the Pat group (indexed with 1, concerns 3 out of 20 in the Pat group, and out of 50 in total). So I am not sure whether to just use 1 group in the group column, or keep the 2 groups but split the nuisance variable into 2 columns. My 1st scenario would look like this: EV1: Con EV2: Pat EV3: Acquisition EV4: Age_Con EV5: Age_Pat C1: 0 0 0 1 -1 C2: 0 0 0 -1 1 C3: 0 0 0 1 0 C4: 0 0 0 0 1 and following Jeanette's advice, I'd be only interested in the interactions (C1 C2) and the individual group slopes (C3 and C4). Note that I am intending to run randomise and feat OLS. Thanks for any suggestion! Cheers, Torsten