Hi, try to: i) generate a CSF mask ii) mask and inverst your FLAIR to obtain an image which has a contrast similar to the T1 iii) register this to MNI iv) apply your registration to the original FLAIR. Let me know if this works. Cheers, Andreas Am 13.01.12 02:52 schrieb "John Smith" unter <[log in to unmask]>: >Thank you for your reply, Mark. > >Unfortunately, I do not have T1 images; I only have FLAIR. > >Regards, >John