Or is there a website I could be referred to? I tried the three designs that made sense to me, but fsl doesn't seem to like them (as per the warning in my first email). I thought a column where controls were 1s, a column were patients were 1s, a column where visit 1 were 1s, and a column where visit 2 were 1s. Maybe it was my contrasts? cv1: control visit 1 cv2: control visit 2 sv1: patient visit 1 sv2: patient visit 2 My contrasts were: c s v1 v2 cv1>cv2 1 0 1 -1 sv1>cv1 -1 1 1 0 . . . ect. On Tue, Jan 17, 2012 at 12:02 PM, Louie Bird <[log in to unmask]>wrote: > Thanks. How would you make a design contrast for 2 groups with two visits > each? > > Thanks so much > > On Jan 17, 2012, at 11:37 AM, Matthew Webster <[log in to unmask]> > wrote: > > > Hello, > > This message is generally a sign that there is an issue with > the design/contrast - it's probably best to kill the randomise task here > and recheck the design. Alternatively you could try re-running the contrast > with a different clustering option than TFCE, but I wouldn't expect the > output to have any significant voxels. > > > > Many Regards > > > > Narrgew > > > >> After successfully running TBSS I wanted to investigate group > comparisons. I made a design matrix/contrast by using glm_gui. I > implemented those files in randomise. The first time I ran it everything > seemed to work fine but I realized that my design was flawed. I made a new > design and attempted again, but received the following message: > >> > >> randomise options: -i all_FA_skeletonised.nii.gz -o ../../TEST/tbss -m > mean_FA_skeleton_mask -d ../../TEST/Test.mat -t ../../TEST/Test.con -n 500 > --T2 -V > >> Loading Data: > >> Data loaded > >> 7.79255e+14 permutations required for exhaustive test of t-test 1 > >> Doing 500 random permutations > >> Starting permutation 1 (Unpermuted data) > >> Starting permutation 2 > >> Warning: tfce has detected a large number of integral steps. This > operation may require a great deal of time to complete. > >> > >> > >> Nothing has changed in 3 days. Can someone tell me what might be wrong? > >> > >> Thanks > >> Lou >