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That assumes that the coregisteration works. For example, if your brain is way off, then it will fail. I would make sure the coregister step works for all my subjects before concluding manual reorientation isn't needed. On Saturday, December 3, 2011, Alejandro Vicente Grabovetsky < [log in to unmask]> wrote: > Personally, I would not worry about the manual reorientation. I believe that coregistering the individual structurals to MNI space prior to DARTEL normalisation should be enough by approximating the "origin (0, 0, 0), and the orientation [of ...] (MNI) space". > On 3 Dec 2011, at 14:58, Peng Syu-Jyun wrote: > > the anatomic images were first manually reoriented so that the > mm coordinate of the anterior commissure matched the origin > (0, 0, 0), and the orientation approximated Montreal Neurological > Institute (MNI) space. > -- Best Regards, Donald McLaren ================= D.G. McLaren, Ph.D. Postdoctoral Research Fellow, GRECC, Bedford VA Research Fellow, Department of Neurology, Massachusetts General Hospital and Harvard Medical School Office: (773) 406-2464 ===================== This e-mail contains CONFIDENTIAL INFORMATION which may contain PROTECTED HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED and which is intended only for the use of the individual or entity named above. If the reader of the e-mail is not the intended recipient or the employee or agent responsible for delivering it to the intended recipient, you are hereby notified that you are in possession of confidential and privileged information. Any unauthorized use, disclosure, copying or the taking of any action in reliance on the contents of this information is strictly prohibited and may be unlawful. If you have received this e-mail unintentionally, please immediately notify the sender via telephone at (773) 406-2464 or email.