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Dear David, Unless you do no smoothing it is unlikely that you would see a lot of benefit from this kind of combination. We do try and reduce the number of steps as it is, so you would, at most, get rid of one intermediate. We also do not recommend slice-timing correction in general, and would advocate using temporal derivatives in the GLM instead. Partly because of this, our slice-timing-correction tool is not quite as well integrated, and I do not think it would be possible with the existing tools to combine this as a transformation that is applied simultaneously with the other spatial transformations. So I'm sorry, but I think the answer here is that you cannot do this, but for the reasons above I personally do not think it is important. All the best, Mark On 8 Dec 2011, at 01:17, David Grayson wrote: > Hi, > > There have been some posts on the listserv about this previously – what I’d like to do is apply all the feat pre-stats steps in one command, to achieve all the preprocessing in one resampling step, instead of multiple stages. It has been argued that this *may* improve power for later analyses, and I think I know how to implement this… > > But my question is this: where then would I apply slice-timing correction? FSL’s standard procedure is to apply it right after mc and fieldmap-correction, but then I’m back to resampling my data more than once; is it equivalent to do slice-timing correction as the very first step instead? > > Thanks for any insights, > > David