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Hi All I'm a new user to FSL's Melodic software suite and am currently having issues getting it to run on my data. I'm using the GUI for Melodic on a 4D dataset made up of 5 3D MRI volumes and am getting the following error in the report_log.html: ... /usr/local/fsl/bin/fslmaths filtered_func_data -Tmean mean_func /bin/rm -rf prefiltered_func_data* An exception has been thrown Logic error:- detected by Newmat: index error: requested index = 2 MatrixType = Rect # Rows = 1; # Cols = 1 Melodic Version 3.10 Melodic results will be in filtered_func_data.ica Create mask ... done Reading data file filtered_func_data ... done Estimating data smoothness ... done Removing mean image ... done Normalising by voxel-wise variance ... done Excluding voxels with constant value ... done ... At this point, the program seems to hang forever which I'm assuming is due to the index error. I've checked using fslview, fslhd and fslinfo that this is indeed a 4D data matrix (176 x 256 x 35 x 5 voxels) and is a NIFTI format file. The following is the header information from fslhd: sizeof_hdr 348 data_type FLOAT32 dim0 4 dim1 176 dim2 256 dim3 35 dim4 5 dim5 1 dim6 1 dim7 1 vox_units mm time_units s datatype 16 nbyper 4 bitpix 32 Running fslstat -r -R yields the following intensity ranges: 0.000 0.747 0.000 3.039 Trying to run this from a MacOSX 10.6 running melodic 3.10, FSL 4.1.6. Any help with this would be greatly appreciated! Thanks in advance!