Hi All,

I searched through FSL archives and came up with following design and contrast matrix for my study I just would like know whether the design is correct in order to proceed further

I have 4 patient subgroups and a control group and I want to exclude the effect of age for comparing GM volume changes using VBM approach

my design matrix is as follows

Ev1 -control, EV2- Patient subgroup 1 (PS1), Ev3 -PS2, EV4 -PS3, EV5-PS4, EV6-age demeaned

design matrix as follows

Group EV1 EV2 EV3 EV4 EV5 EV6 (demeaned age)
1      1   0   0  0   0   -7
...
...
...
...

contrast matrix

1 -1 0 0 0 0 (control vs PS1 regressing out age effects)
1 0 -1 0 0 0  (control vs PS2 regressing out age effects)
...
..
..

Thanks in advance

Venkat

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